{
  "_id": "6acb8027fe5cc25786e90e12",
  "Package": "rema",
  "Title": "Rare Event Meta Analysis",
  "Version": "0.0.1",
  "Authors@R": "c(\nperson(given = \"Brinley N.\",\nfamily = \"Zabriskie\",\nrole = c(\"aut\", \"cre\"),\nemail = \"zabriskie@stat.byu.edu\",\ncomment = c(ORCID = \"0000-0002-2621-7000\")),\nperson(given = \"Benjamin\",\nfamily = \"Kinard\",\nrole = c(\"aut\"),\nemail = \"benjaminjameskinard@gmail.com\"),\nperson(given = \"Chris\",\nfamily = \"Sypherd\",\nrole = c(\"aut\"),\nemail = \"sypherdchris@gmail.com\"),\nperson(given = \"Ryan\",\nfamily = \"Whetten\",\nrole = c(\"aut\"),\nemail = \"whettenrmw@gmail.com\"),\nperson(given = \"Madeleine\",\nfamily = \"Hays\",\nrole = c(\"ctb\"),\nemail = \"madeleine.hays7@gmail.com\"))",
  "Description": "The rema package implements a permutation-based approach\nfor binary meta-analyses of 2x2 tables, founded on conditional\nlogistic regression, that provides more reliable statistical\ntests when heterogeneity is observed in rare event data\n(Zabriskie et al. 2021 <doi:10.1002/sim.9142>). To adjust for\nthe effect of heterogeneity, this method conditions on the\nsufficient statistic of a proxy for the heterogeneity effect as\nopposed to estimating the heterogeneity variance. While this\nresults in the model not strictly falling under the\nrandom-effects framework, it is akin to a random-effects\napproach in that it assumes differences in variability due to\ntreatment. Further, this method does not rely on large-sample\napproximations or continuity corrections for rare event data.\nThis method uses the permutational distribution of the test\nstatistic instead of asymptotic approximations for inference.\nThe number of observed events drives the computation complexity\nfor creating this permutational distribution. Accordingly, for\nthis method to be computationally feasible, it should only be\napplied to meta-analyses with a relatively low number of\nobserved events. To create this permutational distribution, a\nnetwork algorithm, based on the work of Mehta et al. (1992)\n<doi:10.2307/1390598> and Corcoran et al. (2001)\n<doi:10.1111/j.0006-341x.2001.00941.x>, is employed using C++\nand integrated into the package.",
  "License": "GPL (>= 3) | file LICENSE",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.1.1",
  "RdMacros": "Rdpack",
  "Config/testthat/edition": "3",
  "VignetteBuilder": "knitr",
  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-10-11 12:20:17 UTC",
    "User": "root"
  },
  "Author": "Brinley N. Zabriskie [aut, cre]\n(<https://orcid.org/0000-0002-2621-7000>), Benjamin Kinard\n[aut], Chris Sypherd [aut], Ryan Whetten [aut], Madeleine Hays\n[ctb]",
  "Maintainer": "Brinley N. Zabriskie <zabriskie@stat.byu.edu>",
  "Repository": "https://bzabriskie.r-universe.dev",
  "Date/Publication": "2021-10-28 18:30:02 UTC",
  "RemoteUrl": "https://github.com/cran/rema",
  "RemoteRef": "HEAD",
  "RemoteSha": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
  "_user": "bzabriskie",
  "_type": "src",
  "_file": "rema_0.0.1.tar.gz",
  "_fileid": "https://r2.ropensci.org/582816de3449a2c5ac3c2b853186c004319e8a69c6be889105cd8bcee6cfc623",
  "_filesize": 179124,
  "_sha256": "582816de3449a2c5ac3c2b853186c004319e8a69c6be889105cd8bcee6cfc623",
  "_expires": "2027-01-19T12:25:09.000Z",
  "_created": "2026-10-11T12:20:17.000Z",
  "_published": "2026-10-11T12:25:11.447Z",
  "_buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_jobs": [
    {
      "job": 114468458604,
      "time": 90,
      "config": "linux-devel-arm64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11702345024"
    },
    {
      "job": 114468458671,
      "time": 103,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11701388753"
    },
    {
      "job": 114468458656,
      "time": 96,
      "config": "linux-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11701144119"
    },
    {
      "job": 114468458725,
      "time": 110,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11701268762"
    },
    {
      "job": 114468458634,
      "time": 119,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11701508522"
    },
    {
      "job": 114468458677,
      "time": 154,
      "config": "macos-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11702058825"
    },
    {
      "job": 114468458668,
      "time": 111,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11702058746"
    },
    {
      "job": 114468458593,
      "time": 163,
      "config": "macos-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11702073746"
    },
    {
      "job": 114467816669,
      "time": 173,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11702088632"
    },
    {
      "job": 114468458687,
      "time": 91,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "11701423463"
    },
    {
      "job": 114468458641,
      "time": 172,
      "config": "windows-devel-arm64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11701934110"
    },
    {
      "job": 114468458660,
      "time": 122,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11701914013"
    },
    {
      "job": 114468458642,
      "time": 95,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11701954023"
    },
    {
      "job": 114468458672,
      "time": 253,
      "config": "windows-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11701864345"
    },
    {
      "job": 114468458674,
      "time": 97,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11702088824"
    }
  ],
  "_upstream": "https://github.com/cran/rema",
  "_commit": {
    "id": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
    "author": "Brinley N. Zabriskie <zabriskie@stat.byu.edu>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 0.0.1\n",
    "time": 1635445802
  },
  "_maintainer": {
    "name": "Brinley N. Zabriskie",
    "email": "zabriskie@stat.byu.edu",
    "login": "bzabriskie",
    "description": "",
    "uuid": 52466170,
    "orcid": "0000-0002-2621-7000"
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 2.10",
      "role": "Depends"
    },
    {
      "package": "Rcpp",
      "role": "LinkingTo"
    },
    {
      "package": "progress",
      "role": "LinkingTo"
    },
    {
      "package": "graphics",
      "role": "Imports"
    },
    {
      "package": "Rcpp",
      "role": "Imports"
    },
    {
      "package": "Rdpack",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    }
  ],
  "_owner": "cran",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 0,
  "_contributors": [
    {
      "user": "bzabriskie",
      "count": 1,
      "uuid": 52466170
    }
  ],
  "_userbio": {
    "uuid": 52466170,
    "type": "user",
    "name": "Brinley Zabriskie",
    "followers": 1
  },
  "_downloads": {
    "count": 268,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/rema"
  },
  "_searchresults": 40,
  "_topics": [
    "cpp"
  ],
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "extra/rema.html",
    "LICENSE"
  ],
  "_realowner": "bzabriskie",
  "_cranurl": false,
  "_releases": [
    {
      "version": "0.0.1",
      "date": "2021-10-28"
    }
  ],
  "_exports": [
    "rema"
  ],
  "_help": [
    {
      "page": "plot.rema",
      "title": "Plots the distribution of the test statistic results from a 'rema' object",
      "topics": [
        "plot.rema"
      ]
    },
    {
      "page": "rema",
      "title": "A permutation-based approach for heterogeneous meta-analyses of rare events",
      "topics": [
        "rema"
      ]
    }
  ],
  "_readme": "https://github.com/cran/rema/raw/HEAD/README.md",
  "_rundeps": [
    "cli",
    "crayon",
    "glue",
    "hms",
    "lifecycle",
    "pkgconfig",
    "prettyunits",
    "progress",
    "R6",
    "rbibutils",
    "Rcpp",
    "Rdpack",
    "rlang",
    "vctrs"
  ],
  "_sysdeps": [
    {
      "shlib": "libstdc++",
      "package": "libstdc++6",
      "source": "gcc",
      "version": "16-20260322-1ubuntu1",
      "name": "c++",
      "homepage": "http://gcc.gnu.org/",
      "description": "GNU Standard C++ Library v3"
    }
  ],
  "_vignettes": [
    {
      "source": "rema.Rmd",
      "filename": "rema.html",
      "title": "rema",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "The rema package",
        "Example with default values",
        "Example with the one-sided p-value",
        "Example with no mid-p adjustment",
        "Example with alpha set to 0.1"
      ],
      "created": "2021-10-28 18:30:02",
      "modified": "2021-10-28 18:30:02",
      "commits": 1
    }
  ],
  "_score": 3.3010299956639813,
  "_indexed": true,
  "_nocasepkg": "rema",
  "_universes": [
    "bzabriskie"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.0.1",
      "date": "2026-10-11T12:21:55.000Z",
      "distro": "resolute",
      "arch": "aarch64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/a73dc631999828be9d756eba504cc403176de0d1204a5024d95ec04f9ead3c2e",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:07.000Z",
      "distro": "resolute",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/be48ce6f1e00d9b8380563aa12cd2e1cc1b1e76cb0d119839b7f8c738fea6ec7",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:09.000Z",
      "distro": "resolute",
      "arch": "aarch64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/dfde4dcfea0800fc703cd4aec3a699a7e268827266676a9ccd76408c87b95b12",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:09.000Z",
      "distro": "resolute",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/9355580d1de16ab37cc85ded5e4bd8055297f6af0408ca2093ec7c74f3401eb7",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:17.000Z",
      "arch": "aarch64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/fbe5947ae925423c447f502c0dc410e675a0b82b5a41e78a8feab6a54a0eff29",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:41.000Z",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/95f76d259b3df7b0da35d7e0cd3d7094aff1751dac4518765f95ac4a64a540fd",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:14.000Z",
      "arch": "aarch64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/4a599092bb46f005e137d47aa3a670d2d6baea83d8b8d2d46afd66025025a39d",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:45.000Z",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/54fd8d83dc1d114334bf4ff54da969910a2d2c54651f00f6173f7d4f9ea44e33",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.0.1",
      "date": "2026-10-11T12:22:07.000Z",
      "arch": "emscripten",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/65c211670b2b4bacc8d608a4e6d06d4582050804f7a533f301a54e69507e7d8e",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.0.1",
      "date": "2026-10-11T12:23:11.000Z",
      "arch": "aarch64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/a29c53612b08619a5fcc7a5fb7a6690dae555ebe4db1181775208b6d84070ccf",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.0.1",
      "date": "2026-10-11T12:21:23.000Z",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/b4b8d7c1dfd0eec5117fc9516b54df9c35354102ddb9a819e04097deacd710c9",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.0.1",
      "date": "2026-10-11T12:21:23.000Z",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/524520962343518752ef7970690d91001b8b152eaae0318ae5a6396c807e9f6f",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "0.0.1",
      "date": "2026-10-11T12:24:21.000Z",
      "arch": "aarch64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/e5850c82ff0019622ed819ad4fcd1adeb3d04265791191eded3f2b2b50df9778",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "0.0.1",
      "date": "2026-10-11T12:21:31.000Z",
      "arch": "x86_64",
      "commit": "c1324b001f3f711277f1e94d9185b6bb96c90b00",
      "fileid": "https://r2.ropensci.org/a97a0d3c2a5837399f675b76eb8c2bc265cca84335c3c4d299a980a27b0cbcfe",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bzabriskie/actions/runs/38138664932"
    }
  ]
}